Article

Confinement with Myosin-II suppression increases heritable loss of chromosomes, using live-cell ChReporters

2023-02-26

Abstract excerpt

<h4>ABSTRACT</h4> Matrix around cells exerts many effects, some of which depend on the putative tumor suppressor Myosin-II, but whether such factors affect DNA sequences in a cell remains unclear. Here, live-cell monitoring of changes to chromosome copy numbers is developed and studied under diverse perturbations, including Myosin-II inhibition in confined mitosis. Squeezing of mitotic cells is seen in vivo and...

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Literature Corpus work: fe006fea-1294-576c-aef0-1877cc16f701
DOI: 10.1101/2023.02.25.530049

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