Article

Matrix stiffness induces heritable changes in chromosome numbers, consistent with solid tumor heterogeneity

2025-01-30

Abstract excerpt

Solid tumors often have an abundance of collagen-I that stiffens the tissue, and they are invariably driven by mutations that include chromosome losses and gains. These observations are linked here by showing that 3D matrix stiffness induces heritable changes to a cell ’ s DNA. We use live-cell chromosome reporters (ChReporters) and hydrogels of tunable stiffness to show mitotic compression, micronuclei counts, C...

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Literature Corpus work: 53dcdee2-0e67-5a87-a7a3-6ad3dc7f0edb
DOI: 10.1101/2025.01.28.635370

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