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Cell fragmentation in mouse preimplantation embryos induced by ectopic activation of the polar body extrusion pathway

10 Jul 2023

Abstract excerpt

Cell fragmentation is commonly observed in human preimplantation embryos and is associated with poor prognosis during assisted reproductive technology (ART) procedures. However, the mechanisms leading to cell fragmentation remain largely unknown. Here, light sheet microscopy imaging of mouse embryos reveals that inefficient chromosome separation due to spindle defects, caused by dysfunctional molecular motors...

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Identifiers

PMID: 37427462
DOI: 10.15252/embj.2023114415

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