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Article

Artificially decreasing cortical tension generates aneuploidy in mouse oocytes

3 Apr 2020

Abstract excerpt

Human and mouse oocytes' developmental potential can be predicted by their mechanical properties. Their development into blastocysts requires a specific stiffness window. In this study, we combine live-cell and computational imaging, laser ablation, and biophysical measurements to investigate how deregulation of cortex tension in the oocyte contributes to early developmental failure. We focus on extra-soft cells,...

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PMID: 32245998
DOI: 10.1038/s41467-020-15470-y

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