Article

Developmental CA2 perineuronal net reduction restores social memory in <i>Shank3</i> mutant mice

2025-10-14

Abstract excerpt

Individuals with Autism Spectrum Disorder (ASD) and related neurodevelopmental conditions, like Phelan-McDermid syndrome (PMDS), exhibit social recognition deficits. Previous reports using Shank3B knockout (KO) mice, a genetic model with relevance to ASD and PMDS, revealed deficits in social memory in adulthood, but the postnatal onset and mechanisms underlying this dysfunction remain unknown. In the hippocampus,...

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Literature Corpus work: fdd9be42-7bde-5f06-b663-a5134e592821
DOI: 10.1101/2025.10.12.681906

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