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Article

Shank2/3 double knockout-based screening of cortical subregions links the retrosplenial area to the loss of social memory in autism spectrum disorders.

Molecular psychiatry - 1 Dec 2022

Garrido Débora, Beretta Stefania, Grabrucker Stefanie, Bauer Helen Friedericke, Bayer David, Sala Carlo, Verpelli Chiara, Roselli Francesco, Bockmann Juergen, Proepper Christian, Catanese Alberto, Boeckers Tobias M

Abstract excerpt

Members of the Shank protein family are master scaffolds of the postsynaptic architecture and mutations within the SHANK genes are causally associated with autism spectrum disorders (ASDs). We generated a Shank2-Shank3 double knockout mouse that is showing severe autism related core symptoms, as well as a broad spectrum of comorbidities. We exploited this animal model to identify cortical brain areas linked to...

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PMID: 36100669
DOI: 10.1038/s41380-022-01756-8
PMCID: PMC9763120

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