Article

Defective synapse maturation and enhanced synaptic plasticity in Shank2 <sup>-/-</sup> mice

2017-09-29

Abstract excerpt

<h4>Summary</h4> Autism spectrum disorders (ASDs) are neurodevelopmental disorders with a strong genetic aetiology. Since mutations in human SHANK genes have been found in patients with autism, genetic mouse models are employed for a mechanistic understanding of ASDs and the development of therapeutic strategies. In sharp contrast to all studies so far on the function of SHANK proteins, we observe enhanced synapt...

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Literature Corpus work: 0506634a-fb27-585e-b74d-8e4ed8207cde
DOI: 10.1101/193078

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