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First Report of a Novel Pathogenic Variant in the RREB1 Gene Associated With Obesity and Metabolic Syndrome.

Clinical genetics - 1 Jan 2026

Mammadova Nurana, Yildirim A Baki, Hatipoglu Nihal, Dundar Munis

Abstract excerpt

Ras-responsive element binding protein 1 (RREB1) is a zinc finger transcription factor that is crucial in regulating cell growth, gene expression, and DNA repair. It functions as both a repressor and an activator, with its activity controlled by the MAPK signaling pathway. RREB1 has been implicated in various conditions such as type 2 diabetes (T2D), obesity, and cancer, suggesting its potential as both a...

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PMID: 40518752
DOI: 10.1111/cge.70001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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