Article
Ablation of LGR4 promotes energy expenditure by driving white-to-brown fat switch.
Nature cell biology - 1 Dec 2013
Wang Jiqiu, Liu Ruixin, Wang Feng, Hong Jie, Li Xiaoying, Chen Maopei, Ke Yingying, Zhang Xianfeng, Ma Qinyun, Wang Rui, Shi Juan, Cui Bin, Gu Weiqiong, Zhang Yifei, Zhang Zhiguo, Wang Weiqing, Xia Xuefeng, Liu Mingyao, Ning Guang
Abstract excerpt
Obesity occurs when excess energy accumulates in white adipose tissue (WAT), whereas brown adipose tissue (BAT), specialized for energy expenditure through thermogenesis, potently counteracts obesity. Factors that induce brown adipocyte commitment and energy expenditure would be a promising defence against adiposity. Here, we show that Lgr4 homozygous mutant (Lgr4(m/m)) mice show reduced adiposity and resist...
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