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A novel Fis1 inhibiting peptide reverses diabetic endothelial dysfunction in human resistance arteries

2020-11-17

Abstract excerpt

Mitochondrial dysfunction is one of several factors that drive development of vascular endothelial dysfunction in type 2 diabetes (T2DM). In endothelial cells from T2DM patients, mitochondrial networks are highly fragmentated with increased expression of mitochondrial fission protein 1 (Fis1). However, whether manipulation of Fis1 expression and activity in endothelial vessels from T2DM patients alters endothelial...

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Literature Corpus work
fdd513d0-fab4-5565-8ebc-c90748e7fb24
DOI
10.1101/2020.11.16.385054
Open publication

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A novel Fis1 inhibiting peptide reverses diabetic endothelial dysfunction in human resistance arteriesDOI 10.1101/2020.11.16.385054
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