Article

B55α Orchestrates AMPK/SIRT1/HIF-1α Signaling: VCE-005.1 as a Tissue-Selective Therapeutic Strategy for Ischemic Vascular Diseases

2025-03-31

Abstract excerpt

<title>Abstract</title> <p>Peripheral artery disease (PAD) and diabetic foot ulcers (DFUs) are chronic ischemic conditions characterized by endothelial dysfunction, impaired angiogenesis, and tissue hypoxia. The regulatory phosphatase subunit B55α (PP2A) modulates PHD2/HIF-1α axis, supporting vascular homeostasis and repair. Here, we investigated the mechanism and therapeutic potential of VCE-005.1, a selective B...

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Literature Corpus work: af19612d-b718-50fd-8597-76c3e6169e56
DOI: 10.21203/rs.3.rs-6319136/v1

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