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Article

P66Shc-Induced MicroRNA-34a Causes Diabetic Endothelial Dysfunction by Downregulating Sirtuin1.

Arteriosclerosis, thrombosis, and vascular biology - 1 Dec 2016

Li Qiuxia, Kim Young-Rae, Vikram Ajit, Kumar Santosh, Kassan Modar, Gabani Mohanad, Lee Sang Ki, Jacobs Julia S, Irani Kaikobad

Abstract excerpt

OBJECTIVE: Diabetes mellitus causes vascular endothelial dysfunction and alters vascular microRNA expression. We investigated whether endothelial microRNA-34a (miR-34a) leads to diabetic vascular dysfunction by targeting endothelial sirtuin1 (Sirt1) and asked whether the oxidative stress protein p66Shc governs miR-34a expression in the diabetic endothelium. APPROACH AND RESULTS: MiR-34a is upregulated, and Sirt1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27789474
DOI: 10.1161/ATVBAHA.116.308321
PMCID: PMC5293179

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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