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Article

Role of PGC-1α in Vascular Regulation

17 Jun 2016

Abstract excerpt

Mitochondrial dysfunction results in high levels of oxidative stress and mitochondrial damage, leading to disruption of endothelial homeostasis. Recent discoveries have clarified several pathways, whereby mitochondrial dysregulation contributes to endothelial dysfunction and vascular disease burden. One such pathway centers around peroxisome proliferator receptor-γ coactivator 1α (PGC-1α), a transcriptional...

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PMID: 27312223
DOI: 10.1161/atvbaha.116.307123

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