Article

Stress-induced mitochondrial fragmentation in endothelial cells disrupts blood-retinal barrier integrity causing neurodegeneration

2024-12-22

Abstract excerpt

<h4>ABSTRACT</h4> Increased vascular leakage and endothelial cell (EC) dysfunction are major features of neurodegenerative diseases. Here, we investigated the mechanisms leading to EC dysregulation and asked whether altered mitochondrial dynamics in ECs impinge on vascular barrier integrity and neurodegeneration. We show that ocular hypertension, a major risk factor to develop glaucoma, induced mitochondrial frag...

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Identifiers and source

Literature Corpus work: 8766340b-655a-5403-b3de-048f09277de1
DOI: 10.1101/2024.12.21.629919

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