Article

Schizophrenia risk variants modulate transcription factor binding and gene expression in cortical cell types

2025-03-17

Abstract excerpt

<h4>Background</h4> Schizophrenia is a complex neuropsychiatric disorder with a strong genetic component. Genome-wide association studies (GWAS) have identified numerous risk variants, but their functional impact on gene regulation remains largely unknown. A major challenge lies in interpreting the function of non-coding variants, which comprise the majority of GWAS hits, making it difficult to determine their fun...

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Literature Corpus work: fdd3b475-f1c3-5478-80ba-6e6bb19d23ff
DOI: 10.1101/2025.03.17.25324098

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