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Article

Molecular regulatory mechanisms of schizophrenia-associated functional non-coding variants.

Molecular psychiatry - 1 Aug 2026

Dai Shan-Shan, Dang Xinglun, Gong Daohua, Li Danyang, Mu Changgai, Teng Zhaowei, Luo Xiong-Jian

Abstract excerpt

Genome-wide association studies (GWAS) have identified over 300 risk loci for schizophrenia (SCZ). However, given the vast majority of risk variants identified from GWAS are localized in non-coding regions, identification of functional risk variants from the risk loci and elucidating their molecular regulatory mechanisms remain major challenges. Here, we leverage a functional genomics approach to systematically...

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PMID: 41927765
DOI: 10.1038/s41380-026-03566-8

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