Article

Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights

2016-08-02

Abstract excerpt

<h4>ABSTRACT</h4> Genome-wide association studies (GWAS) have identified over 100 risk loci for schizophrenia, but the causal mechanisms remain largely unknown. We performed a transcriptome-wide association study (TWAS) integrating expression data from brain, blood, and adipose tissues across 3,693 individuals with schizophrenia GWAS of 79,845 individuals from the Psychiatric Genomics Consortium. We identified 15...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 41f60e2c-189e-57a9-aa8b-bc58b6530779
DOI: 10.1101/067355

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insightsDOI 10.1101/067355Read

Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights.Semantic proximity Read

Splicing-specific transcriptome-wide association uncovers genetic mechanisms for schizophrenia.Semantic proximity Read

Multi-omic transcriptional, brain, and clinical variations in schizophreniaSemantic proximity Read

Genome-wide identification of splicing QTLs in the human brain and their enrichment among schizophrenia-associated loci.Semantic proximity Read

Biological Insights from Schizophrenia-associated Loci in Ancestral PopulationsSemantic proximity Read

Transcriptome Sequencing Revealed Significant Alteration of Cortical Promoter Usage and Splicing in SchizophreniaSemantic proximity Read

Developmental and genetic regulation of the human cortex transcriptome in schizophreniaSemantic proximity Read

Expression QTL analysis of top loci from GWAS meta-analysis highlights additional schizophrenia candidate genes.Semantic proximity Read

Schizophrenia risk variants modulate transcription factor binding and gene expression in cortical cell typesSemantic proximity Read

Integrating genome-wide association study and expression quantitative trait locus study identifies multiple genes and gene sets associated with schizophrenia.Semantic proximity Read

A transcriptomic atlas of the human brain reveals genetically determined aspects of neuropsychiatric health.Semantic proximity Read

Evaluation of Chromatin Accessibility in Prefrontal Cortex of Schizophrenia Cases and ControlsSemantic proximity Read