Article

Specific genomic targeting of the RNF12/RLIM E3 ubiquitin ligase selectively programmes developmental transcription

2023-06-14

Abstract excerpt

<h4>Summary</h4> The E3 ubiquitin ligase RNF12/RLIM controls developmental gene expression and is mutated in the X-linked intellectual disability disorder Tonne-Kalscheuer syndrome (TOKAS). However, the mechanisms by which RNF12 E3 ubiquitin ligase activity controls specific gene expression signatures are not known. Here, we show that chromatin forms a regulatory platform for RNF12 substrate ubiquitylation and tr...

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Literature Corpus work: fdcd04a9-f2d0-57a9-ad1f-37a19e876649
DOI: 10.1101/2023.06.14.544957

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Specific genomic targeting of the RNF12/RLIM E3 ubiquitin ligase selectively programmes developmental transcriptionDOI 10.1101/2023.06.14.544957Read

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