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Article

REX1 is the critical target of RNF12 in imprinted X chromosome inactivation in mice

6 Nov 2018

Abstract excerpt

Abstract In mice, imprinted X chromosome inactivation (iXCI) of the paternal X in the pre-implantation embryo and extraembryonic tissues is followed by X reactivation in the inner cell mass (ICM) of the blastocyst to facilitate initiation of random XCI (rXCI) in all embryonic tissues. RNF12 is an E3 ubiquitin ligase that plays a key role in XCI. RNF12 targets pluripotency protein REX1 for degradation to initiate...

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PMID: 30420655
DOI: 10.1038/s41467-018-07060-w

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