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Article

Emerging roles for E3 ubiquitin ligases in neural development and disease

27 May 2025

Abstract excerpt

Neurodevelopment is an intricate process with highly regulated, overlapping stages including neuronal differentiation and axon guidance. Aberrations during these and other stages are tied to the etiology of neurodevelopmental disorders like Autism Spectrum Disorder, Angelman Syndrome, and X-linked Intellectual Disability. Ubiquitination is a dynamic and highly reversible post-translational modification conferred...

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PMID: 40496139
DOI: 10.3389/fcell.2025.1557653

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