Article

BAP1 deubiquitinase is a potent repressor of fetal hemoglobin biosynthesis

2018-06-13

Abstract excerpt

<h4>Summary</h4> Human globin gene production transcriptionally “switches” from fetal to adult synthesis shortly after birth, and is controlled by macromolecular complexes that enhance or suppress transcription by cis-elements scattered throughout the locus. The DRED repressor is recruited to the ε- and γ-globin promoters by the orphan nuclear receptors TR2 (NR2C1) and TR4 (NR2C2) to engender their silencing in a...

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Literature Corpus work: 74865ed8-aad2-5d82-b9fc-286a2381e2ec
DOI: 10.1101/346619

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