Article

Epigenetic regulation of unique genes and repetitive elements by the KRAB zinc finger protein ZFP57

2019-04-18

Abstract excerpt

<h4>Background</h4> KRAB-zinc finger proteins (KZFPs) represent one of the largest families of DNA binding proteins in vertebrate genomes and appear to have evolved to silence transposable elements (TEs) including endogenous retroviruses through sequence-specific targeting of repressive chromatin states. ZFP57 is required to maintain the post-fertilization DNA methylation memory of parental-origin at genomic impr...

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Literature Corpus work: 17ea6e94-ac21-5424-815e-4a4f3707d95c
DOI: 10.1101/611400

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