Article

N-Terminal Deleted Isoforms of E3 Ligase RNF220 (Isoform 4) Are Ubiquitously Expressed and Required for Mouse Muscle Differentiation

2025-04-09

Abstract excerpt

Four isoform peptides of the novel E3 ligase RNF220 have been identified in humans. However, all of previous studies have predominantly focused on isoform 1, which consists of 566 amino acids (aa). Here, we show that a shorter isoform, isoform 4 (308 aa), lacking most of the N-terminus, is the predominant and ubiquitously expressed variant that warrants functional investigation. Both isoform 1 and isoform 4 are ex...

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Literature Corpus work: 9c8faba1-e1e7-559b-a911-74ad242dfce8
DOI: 10.1101/2025.04.07.647521

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