Article
An RNF12-USP26 amplification loop drives germ cell specification and is disrupted by disease-associated mutations.
Science signaling - 12 Jul 2022
Segarra-Fas Anna, Espejo-Serrano Carmen, Bustos Francisco, Zhou Houjiang, Wang Feng, Toth Rachel, Macartney Thomas, Bach Ingolf, Nardocci Gino, Findlay Greg M
Abstract excerpt
The E3 ubiquitin ligase RNF12 plays essential roles during development, and the gene encoding it, RLIM, is mutated in the X-linked human developmental disorder Tonne-Kalscheuer syndrome (TOKAS). Substrates of RNF12 include transcriptional regulators such as the pluripotency-associated transcriptional repressor REX1. Using global quantitative proteomics in male mouse embryonic stem cells, we identified the...
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