Article

APC2 is Critical for Ovarian WNT Signalling Control, Fertility and Tumour Suppression

2019-01-10

Abstract excerpt

Canonical WNT signalling plays a critical role in the regulation of ovarian development; mis-regulation of this key pathway in the adult ovary is associated with subfertility and tumourigenesis. The roles of Adenomatous polyposis coli 2 (APC2), a little-studied WNT signalling pathway regulator, in ovarian homeostasis, fertility and tumourigenesis have not previously been explored. Here, we demonstrate for the firs...

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Literature Corpus work: fd980ddc-d019-5481-8bd4-c818357c2945
DOI: 10.1101/516286

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