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Article

Global or Granulosa Cell-Specific Pten Mutations in Combination with Elevated FSH Levels Fail to Cause Ovarian Tumours in Mice.

Hormones & cancer - 1 Dec 2016

Upton Dannielle H, Walters Kirsty A, Allavena Rachel E, Jimenez Mark, Desai Reena, Handelsman David J, Allan Charles M

Abstract excerpt

Phosphatase and tensin homologue (PTEN) is a known tumour suppressor. To explore the role of Pten in ovarian tumorigenesis, we used transgenic (Tg) SOX2. Cre and AMH. Cre mouse models to direct global Pten haploinsufficiency (Pten +/-) or ovary-specific granulosa cell (GC) Pten disruption (Pten GC ). Pten mutant models were combined with progressively rising Tg-follicle-stimulating hormone (TgFSH) levels to study...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27506975
DOI: 10.1007/s12672-016-0272-3
PMCID: PMC10355859

Genes

AMH
PTEN
SOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Global or Granulosa Cell-Specific Pten Mutations in Combination with Elevated FSH Levels Fail to Cause Ovarian Tumours in Mice.PMID 27506975Read ↗

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Subtle variations in Pten dose determine cancer susceptibility.Semantic proximity Read ↗

APC2 is Critical for Ovarian WNT Signalling Control, Fertility and Tumour SuppressionSemantic proximity Read ↗

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