Article
Testing hypotheses for the functions of APC family proteins using null and truncation alleles in Drosophila.
Development (Cambridge, England) - 1 Jun 2006
McCartney Brooke M, Price Meredith H, Webb Rebecca L, Hayden Melissa A, Holot Lesley M, Zhou Mengning, Bejsovec Amy, Peifer Mark
Abstract excerpt
Adenomatous polyposis coli (APC) is mutated in colon cancers. During normal development, APC proteins are essential negative regulators of Wnt signaling and have cytoskeletal functions. Many functions have been proposed for APC proteins, but these have often rested on dominant-negative or partial loss-of-function approaches. Thus, despite intense interest in APC, significant questions remain about its full range...
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