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The Oncogenic FOXL2 C134W Mutation Is a Key Driver of Granulosa Cell Tumors.

Cancer research - 18 Jan 2023

Llano Elena, Todeschini Anne Laure, Felipe-Medina Natalia, Corte-Torres María D, Condezo Yazmine B, Sanchez-Martin Manuel, López-Tamargo Sara, Astudillo Aurora, Puente Xose S, Pendas Alberto M, Veitia Reiner A

Abstract excerpt

Adult-type granulosa cell tumors (AGCT) are the most common type of malignant ovarian sex cord-stromal tumors. Most AGCTs carry the somatic variant c.402C>G (p.C134W) affecting the transcription factor FOXL2. Germline dominant variants in FOXL2 are responsible for blepharophimosis syndrome, which is characterized by underdevelopment of the eyelid. In this work, we generated a mouse model harboring the C134W...

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PMID: 36409821
DOI: 10.1158/0008-5472.CAN-22-1880

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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