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Article

The murine winged-helix transcription factor Foxl2 is required for granulosa cell differentiation and ovary maintenance.

Development (Cambridge, England) - 1 Feb 2004

Schmidt Dirk, Ovitt Catherine E, Anlag Katrin, Fehsenfeld Sandra, Gredsted Lars, Treier Anna-Corina, Treier Mathias

Abstract excerpt

Human Blepharophimosis/ptosis/epicanthus inversus syndrome (BPES) type I is an autosomal dominant disorder associated with premature ovarian failure (POF) caused by mutations in FOXL2, a winged-helix/forkhead domain transcription factor. Although it has been shown that FOXL2 is expressed in adult ovaries, its function during folliculogenesis is not known. Here, we show that the murine Foxl2 gene is essential for...

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Source

Identifiers

PMID: 14736745
DOI: 10.1242/dev.00969

Genes

FOXL2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The murine winged-helix transcription factor Foxl2 is required for granulosa cell differentiation and ovary maintenance.PMID 14736745Read ↗

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Minireview: Roles of the Forkhead Transcription Factor FOXL2 in Granulosa Cell Biology and PathologySemantic proximity Read ↗

FOXL2: a gene central to ovarian function.Semantic proximity Read ↗

FOXL2 Is an Essential Activator of SF-1-Induced Transcriptional Regulation of Anti-Müllerian Hormone in Human Granulosa Cells.Semantic proximity Read ↗

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