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Article

Aberrant and constitutive expression of FOXL2 impairs ovarian development and functions in mice.

Biology of reproduction - 29 Oct 2020

Nicol Barbara, Rodriguez Karina, Yao Humphrey H-C

Abstract excerpt

Development and functions of the ovary rely on appropriate signaling and communication between various ovarian cell types. FOXL2, a transcription factor that plays a key role at different stages of ovarian development, is associated with primary ovarian insufficiency and ovarian cancer as a result of its loss-of-function or mutations. In this study, we investigated the impact of aberrant, constitutive expression...

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Share to Cell Differentiation
Share to Forkhead Box Protein L2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32945847
DOI: 10.1093/biolre/ioaa146
PMCID: PMC7609876

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