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Article

Effects of a mutation in the transmembrane and coiled-coil domains 2 gene on ovarian function and reproductive aging.

Maturitas - 1 Apr 2026

Xu Che, Ruan Xiangyan, Li Yanqiu, Yang Yu, Wang Zecheng, Liu Anming, Cheng Jiaojiao, Gu Muqing, Mueck Alfred O

Abstract excerpt

OBJECTIVES: A mutation in the transmembrane and coiled-coil domain 2 (TMCO2) gene was identified in a family with premature ovarian insufficiency (POI). To determine whether the TMCO2 mutation causes the decline in ovarian function, Tmco2-deficient mice were bred and studied. DESIGN: The F2 generation of Tmco2-deficient mice was obtained, and the breeding outcomes were assessed. Physical characteristics of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41722335
DOI: 10.1016/j.maturitas.2026.108885

Genes

TMCO2
AMH
F2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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