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Article

Germ cell specific overactivation of WNT/βcatenin signalling has no effect on folliculogenesis but causes fertility defects due to abnormal foetal development.

Scientific reports - 6 Jun 2016

Kumar Manish, Camlin Nicole J, Holt Janet E, Teixeira Jose M, McLaughlin Eileen A, Tanwar Pradeep S

Abstract excerpt

All the major components of the WNT signalling pathway are expressed in female germ cells and embryos. However, their functional relevance in oocyte biology is currently unclear. We examined ovaries collected from TCFGFP mice, a well-known Wnt reporter mouse model, and found dynamic changes in the Wnt/βcatenin signalling activity during different stages of oocyte development and maturation. To understand the...

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Identifiers

PMID: 27265527
DOI: 10.1038/srep27273
PMCID: PMC4893675

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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