Article

An mTOR-independent Macroautophagy Activator Ameliorates Tauopathy and Prionopathy Neurodegeneration Phenotypes

2022-09-30

Abstract excerpt

<h4>Summary</h4> Autophagy-lysosomal impairment is an early and prominent feature of neurodegeneration. Autophagy activation reduces protein aggregates and lipid level abnormalities. We performed a high-content imaging-based screen assessing 940,000 small molecules to identify those that reduce lipid droplet numbers. Of 77 validated, structurally diverse hits, 24 increased autophagy flux reporter activity, consis...

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Literature Corpus work: 4fa261c4-87e0-5036-abdc-38b1893f9b5d
DOI: 10.1101/2022.09.29.509997

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