Article

The nuclear role of methionine adenosyltransferase 2A in immunoglobulin class switch recombination

2025-10-25

Abstract excerpt

Methionine adenosyltransferase synthesizes S-adenosylmethionine (SAM), the universal methyl donor. Its ubiquitous isozyme MAT2 is present in the nucleus and regulates gene expression through histone methylation. However, the physiological significance of its nuclear enzymatic activity remains unclear. Here, we investigate the role of nuclear MAT2 in antibody class switch recombination (CSR), a crucial process in a...

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Literature Corpus work: fd59a08c-8c55-5fd3-900a-56cdb884e2c7
DOI: 10.1101/2025.10.24.684368

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