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Article

YY1 Controls Immunoglobulin Class Switch Recombination and Nuclear Activation-Induced Deaminase Levels

31 Jan 2012

Abstract excerpt

Activation-induced deaminase (AID) is an enzyme required for class switch recombination (CSR) and somatic hypermutation (SHM), processes that ensure antibody maturation and expression of different immunoglobulin isotypes. AID function is tightly regulated by tissue- and stage-specific expression, nuclear localization, and protein stability. Transcription factor YY1 is crucial for early B cell development, but its...

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PMID: 22290437
DOI: 10.1128/mcb.05989-11

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YY1 Controls Immunoglobulin Class Switch Recombination and Nuclear Activation-Induced Deaminase LevelsPMID 22290437Read ↗

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