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Article

Transcript splicing optimizes the thymic self-antigen repertoire to suppress autoimmunity

14 Oct 2024

Abstract excerpt

Immunological self-tolerance is established in the thymus by the expression of virtually all self-antigens, including tissue-restricted antigens (TRAs) and cell-type-restricted antigens (CRAs). Despite a wealth of knowledge about the transcriptional regulation of TRA genes, posttranscriptional regulation remains poorly understood. Here, we show that protein arginine methylation plays an essential role in central...

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PMID: 39403924
DOI: 10.1172/jci179612

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