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Article

Inactivation of NuRD component Mta2 causes abnormal T cell activation and lupus-like autoimmune disease in mice.

The Journal of biological chemistry - 16 May 2008

Lu Xiangdong, Kovalev Grigoriy I, Chang Hua, Kallin Eric, Knudsen Geoffrey, Xia Li, Mishra Nilamadhab, Ruiz Phillip, Li En, Su Lishan, Zhang Yi

Abstract excerpt

Dynamic changes in chromatin structure through ATP-dependent remodeling and covalent modifications on histones play important roles in transcription regulation. Among the many chromatin modifiers identified, the NuRD (nucleosome remodeling histone deacetylase) complex is unique because it possesses both nucleosome remodeling and histone deacetylase activities. To understand the biological function of the NuRD...

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Identifiers

PMID: 18353770
DOI: 10.1074/jbc.M801275200
PMCID: PMC2376246

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Inactivation of NuRD component Mta2 causes abnormal T cell activation and lupus-like autoimmune disease in mice.PMID 18353770Read ↗

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NuRD independent Mi-2 activity represses ectopic gene expression during neuronal maturationSemantic proximity Read ↗

MBD2 acts as a repressor to maintain the homeostasis of the Th1 program in type 1 diabetes by regulating the STAT1-IFN-γ axisSemantic proximity Read ↗

Dual genomic localizations and gene regulatory functions of MBD-2 with and without NuRD in Caenorhabditis elegans which lacks DNA methylation.Semantic proximity Read ↗

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SETDB1-like MET-2 promotes transcriptional silencing and development independently of its H3K9me-associated catalytic activity.Semantic proximity Read ↗

p66alpha and p66beta of the Mi-2/NuRD complex mediate MBD2 and histone interaction.Semantic proximity Read ↗

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