Article

Human iPSC-based modeling reveals coding and non-coding transcriptomic alterations associated with RFX3 deficiency in pancreatic islets

2025-09-12

Abstract excerpt

<title>Abstract</title> Background RFX3 is a transcription factor (TF) critical for pancreatic endocrine development. Its loss impairs β-cell differentiation, promotes enterochromaffin cell (EC) generation, and induces apoptosis. However, the role of non-coding RNAs in mediating these effects remains poorly understood. Methods Using CRISPR/Cas9-derived RFX3 knockout (KO) human iPSC-derived pancreatic islets,...

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Literature Corpus work: bd5230bc-4907-5932-a5e3-46528f0704b6
DOI: 10.21203/rs.3.rs-7435927/v1

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