Article

Coevolution in Small Heat Shock Protein 1 (HSPB1) is Promoted by Interactions between the Alpha-Crystallin Domain and the Disordered Regions

2024-12-04

Abstract excerpt

Human HSPB1, a member of the small heat shock protein (sHSP) family, functions as an ATP-independent molecular chaperone crucial for protein quality control and is implicated in several pathologies, including Charcot-Marie-Tooth neuropathy. This study investigates the coevolution of the disordered N-terminal and C-terminal regions (NTR and CTR) with the structured Alpha-Crystallin domain (ACD) of human HSPB1, focu...

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Literature Corpus work: fd1a29ef-03a9-5c4a-9ea4-a471d98778a0
DOI: 10.1101/2024.12.03.626587

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Coevolution in Small Heat Shock Protein 1 (HSPB1) is Promoted by Interactions between the Alpha-Crystallin Domain and the Disordered RegionsDOI 10.1101/2024.12.03.626587Read

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