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Article

Human HspB1, HspB3, HspB5 and HspB8: Shaping these disease factors during vertebrate evolution.

Cell stress & chaperones - 1 Jul 2022

Benndorf Rainer, Velazquez Ryan, Zehr Jordan D, Pond Sergei L Kosakovsky, Martin Jody L, Lucaci Alexander G

Abstract excerpt

Small heat shock proteins (sHSPs) emerged early in evolution and occur in all domains of life and nearly in all species, including humans. Mutations in four sHSPs (HspB1, HspB3, HspB5, HspB8) are associated with neuromuscular disorders. The aim of this study is to investigate the evolutionary forces shaping these sHSPs during vertebrate evolution. We performed comparative evolutionary analyses on a set of...

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Identifiers

PMID: 35678958
DOI: 10.1007/s12192-022-01268-y
PMCID: PMC9346038

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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