Article

Dysregulated interactions triggered by a neuropathy-causing mutation in the IPV motif of HSP27

2019-07-19

Abstract excerpt

HSP27 (HSPB1) is a systemically expressed human small heat-shock protein that forms large, dynamic oligomers and functions in various aspects of cellular homeostasis. Mutations in HSP27 cause Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. A particularly severe form of the disease is triggered by the P182L mutation within the highly conserved IxI/V motif of HSP27....

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Literature Corpus work: c70d1b2b-70d3-53ed-b70f-f59fcc49399a
DOI: 10.1101/708180

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