Article
Concurrent action of purifying selection and gene conversion results in extreme conservation of the major stress-inducible Hsp70 genes in mammals.
Scientific reports - 23 Mar 2018
Hess Kyle, Oliverio Ryan, Nguyen Peter, Le Dat, Ellis Jacqueline, Kdeiss Brianna, Ord Sara, Chalkia Dimitra, Nikolaidis Nikolas
Abstract excerpt
Several evolutionary mechanisms alter the fate of mutations and genes within populations based on their exhibited functional effects. To understand the underlying mechanisms involved in the evolution of the cellular stress response, a very conserved mechanism in the course of organismal evolution, we studied the patterns of natural genetic variation and functional consequences of polymorphisms of two...
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