Article

Activation mechanism of Small Heat Shock Protein HSPB5 revealed by disease-associated mutants

2022-05-30

Abstract excerpt

Found from bacteria to humans, small heat shock proteins (sHSPs) are the least understood protein chaperones. HSPB5 (or αB-crystallin) is among the most widely expressed of the ten human sHSPs, including in muscle, brain, and eye lens where it is constitutively present at very high levels and carries out a myriad of functions. A high content of disorder in HSPB5 has stymied efforts to uncover how its structure giv...

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Literature Corpus work: 1427079f-b12b-569c-ba90-a4c3a878a0d6
DOI: 10.1101/2022.05.30.493970

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