Article

Buffering role of HSP shapes the molecular evolution of mammalian and human genomes at short and long-term scales

2022-11-14

Abstract excerpt

<h4>ABSTRACT</h4> Heat shock proteins in parallel with their main and originally discovered function – maintenance of folded proteins under stressful conditions, can play also background buffering role – by folding proteins with an excess of slightly-deleterious nonsynonymous variants (SDNV). Here we tested several scenarios of this buffering role. On the comparative species scale, we demonstrated that low-Ne spe...

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Literature Corpus work: a9e0024e-2f28-5c97-b90e-2fd1b0356b05
DOI: 10.1101/2022.11.11.516130

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