Article

Proteostasis Associated Mutations in HSPB5 Destabilize the αB-crystallin Domain

2024-11-15

Abstract excerpt

HSPB5 (αB-crystallin) is an ATP-independent, stress-inducible chaperone protein that improves protein misfolding and degradation in proteotoxicity-related diseases, including several myopathies, neurodegenerative diseases, and cancers. Although single nucleotide polymorphism (SNP) reduces the overall activity of HSPB5, its dynamic behaviour remains unknown. To get molecular insights into the deleterious, pathogeni...

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Literature Corpus work: 50d9e9e1-268b-5d24-b2fd-81543c341f15
DOI: 10.1101/2024.11.12.623266

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