Article

Data-driven large-scale genomic analysis reveals an intricate phylogenetic and functional landscape in J-domain proteins

2022-03-02

Abstract excerpt

The 70 kDalton Heat shock protein (Hsp70) chaperone system is emerging as a central hub of the proteostasis network that helps maintain protein homeostasis in all organisms. The recruitment of Hsp70 to perform a vast array of different cellular functions is regulated by a family of co-chaperones known as J-domain proteins (JDP) that bear a small namesake J-domain, which is required to interact and drive the ATPase...

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Literature Corpus work: 5ca63dd7-fe56-518b-9cac-bc4f459115c7
DOI: 10.1101/2022.02.28.482344

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