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Article

In silico evaluation of human small heat shock protein HSP27: homology modeling, mutation analyses and docking studies.

Bioorganic & medicinal chemistry - 1 Jul 2015

Fossa Paola, Cichero Elena

Abstract excerpt

Small heat-shock proteins, possessing chaperone-like activity, represented crucial proteins actively involved in maintain protein homeostasis, which act to prevent improper polypeptide aggregation and deposition of misfolded proteins. In this context, a number of mutations concerning the HspB1 protein proved to be associated with the development of several neuropathologies. Unfortunately, molecular mechanisms...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25999205
DOI: 10.1016/j.bmc.2015.04.070

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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