Article

Reduction of RAD23A extends lifespan and mitigates pathology in TDP-43 mice

2024-09-11

Abstract excerpt

<title>Abstract</title> <p>Protein misfolding and aggregation are cardinal features of neurodegenerative disease (NDD) and they contribute to pathophysiology by both loss-of-functon(LOF) and gain-of-functon(GOF) mechanisms. This is well exemplified by TDP-43 which aggregates and mislocalizes in several NDDs. The depletion of nuclear TDP-43 leads to reduction in its normal function in RNA metabolism and the cytopl...

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Literature Corpus work: fd046cf5-dc4a-5049-a982-119d88d80f6b
DOI: 10.21203/rs.3.rs-5032280/v1

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