Challenges of modelling TDP-43 pathology in mice.

Abstract excerpt

TDP-43 is a normally nuclear RNA binding protein that under pathological conditions may be excluded from the nucleus and deposited in the cytoplasm in the form of insoluble polyubiquitinated and polyphosphorylated inclusions. This nuclear exclusion coupled with cytoplasmic accumulation is called TDP-43 pathology and contributes to a range of disorders collectively known as TDP-43 proteinopathies. These include...

Topics

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• Amyotrophic Lateral Sclerosis
• Cell Nucleus
• Cytoplasm
• Disease Models, Animal
• DNA-Binding Proteins