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RNA-Processing Protein TDP-43 Regulates FOXO-Dependent Protein Quality Control in Stress Response

16 Oct 2014

Abstract excerpt

Protein homeostasis is critical for cell survival and functions during stress and is regulated at both RNA and protein levels. However, how the cell integrates RNA-processing programs with post-translational protein quality control systems is unknown. Transactive response DNA-binding protein (TARDBP/TDP-43) is an RNA-processing protein that is involved in the pathogenesis of major neurodegenerative diseases,...

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PMID: 25329970
DOI: 10.1371/journal.pgen.1004693

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